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When liver damage outpaces the rate of liver cell regeneration, scarring of the liver can gradually lead to cirrhosis (permanent scarring and hardening of liver tissue).

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Chronic liver disease severity is determined by the liver’s landscape; the more liver cells that are damaged and scarred, the more advanced the liver disease is.

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In general, the histological staging systems for liver fibrosis currently used derive from the initial Knodell fibrosis score, and consist of either a five or seven tier rating.

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In liver tissue, scarring is an accumulation of extracellular matrix components.


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